The Non-Contraceptive Benefits of Zoely: What Women in the UK Should Know

If you’re looking for a birth control pill that’s a little different from the usual options, Zoely might be worth knowing about. Approved by the European Medicines Agency in 2011, it combines two hormones—Nomegestrol acetate (NOMAC), a type of progestin, and estradiol (E2), a form of estrogen identical to what your body naturally produces.

Like many combined oral contraceptives (COCs), Zoely follows a cyclical pattern, however there is only a 4 day break compare to the traditional 7: 24 days of active pills, followed by four placebo pills. This short hormone-free window is possible thanks to NOMAC’s long-lasting effects, which help keep ovulation under control.

How Does It Compare to Other Pills?

Most COCs contain synthetic estrogens like ethinylestradiol (EE) combined with progestins such as levonorgestrel or norethisterone. While those are considered the standard go-to options, Zoely offers some interesting differences:
Lower impact on blood clotting risks – Studies suggest it may have a lower impact on clotting factors compared to other pills.
Better for metabolism – Zoely seems to have a more neutral effect on blood sugar and cholesterol levels than some older formulations.
Improved bleeding patterns – Many users report lighter and more predictable periods, or even the occasional skipped period.

Non-contraceptive benefits

1. Alleviating Premenstrual Dysphoric Disorder (PMDD)

PMDD is a severe form of premenstrual syndrome (PMS) that can cause extreme mood swings, irritability, and depression, making it difficult for women to function normally. For women who experience PMDD, Zoely can provide relief by stabilising hormone levels throughout the menstrual cycle. By doing so, it helps reduce the emotional and physical symptoms linked to PMDD, making it easier for women to go about their daily activities without the debilitating effects of this condition. Zoely has yet to be studied compared to Yacelle (EE/drosperinone), which is the commonly prescribed COC for PMDD, but specialists are using it on a case by case basis due to its favourable blood clot risk.

2. Menstrual migraines

The COC is contraindicated in women who experience migraines with aura, but can actually improve symptoms in migraine without aura as there is evidence that abrupt estrogen withdrawal at the end of the menstrual cycle may be one mechanism that triggers migraine attacks (it should be taken as an extended regime, with limit breaks to prevent estrogen withdrawal). As with menstrual migraines, Zoely has yet to be studied compared to traditional COCs, however it is a favoured option by migraine specialists due to its favourable blood clot and cardiovascular profile.

3. Contraception over the age of 40

Contraception is recommended until age 55 or for one year after your last period if you’re over 50 (or two years if you’re under 50). This means many women in their 40s are looking for options that provide both contraception and relief from perimenopausal symptoms. Zoely contains a body-identical estrogen, similar to oral HRT, which may help manage perimenopausal symptoms more effectively than traditional combined pills (COCs) that use synthetic ethinylestradiol (EE). Early perimenopause is marked by high estrogen levels, with frequent fluctuations in a levels, and low progesterone, and Zoely works by suppressing natural ovarian function while delivering a steady, balanced dose of both hormones. Some women find this more beneficial than standard HRT. Additionally, Zoely carries a lower risk of blood clots in women over 40 and has more favourable metabolic effects compared to some COCs—important considerations as these risks naturally increase with age. For those wanting a single solution for contraception and hormone support, Zoely can be a great option.

Is Zoely Right for You?

The non-contraceptive benefits of Zoely make it an appealing option for many women. However, as with any medication, it’s important to discuss your options with your healthcare provider. They can help determine if Zoely is suitable for your individual needs, especially if you’re managing specific health conditions like PMDD, menstrual migraines and perimenopause.

When choosing a contraceptive method, it’s essential to consider all aspects, including both the contraceptive and non-contraceptive benefits. Zoely may be the key to not only preventing pregnancy but also improving your overall health and well-being.

If you’re in the UK and looking to explore your options, don’t hesitate to book an appointment with Sirona Health to discuss how Zoely could be the right choice for you.

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