Berberine for PCOS
Berberine is a compound present in various plants like goldenseal, barberry, Oregon grape, and more, with a rich history in Ayurvedic and Chinese medicine. The amount absorbed from taking these plants directly is not sufficient and therefore it must be taken as a concentrated supplement.
Research indicates that in individuals with PCOS, berberine, taken at doses between 300 mg/d and 2000 mg/d, might have a positive impact on pregnancy and conception. It could help lower testosterone levels and the LH to FSH ratio compared to a placebo or no treatment. However, whether this is a direct effect or due to berberine's influence on factors like glucose and lipid regulation remains uncertain.
There is some promising new research looking at the role of berberine on the microbiome, and it appears as if it might help to improve the ‘good’ bacteria and reduce the ‘bad’ bacteria. New research is also looking into the role of the microbiome in causing PCOS. This is still very much in the ‘experimental’ phase but might hint at other benefical mechanisms of action of berberine in PCOS.
It has not been recommended by the International Evidence-based Guideline for the assessment and management of polycystic ovary syndrome 2023, and evidence in support of its use does not seem to have been considered. The only supplement that they considered in their guidelines was inositol, which they advised “could be considered in women with PCOS based on individual preferences and values, noting limited harm, potential for improvement in metabolic measures, yet with limited clinical benefits including in ovulation, hirsutism or weight”.
Some studies have noted gastrointestinal side effects such as nausea, abdominal pain, bloating, constipation, or diarrhoea associated with berberine use.
Berberine exposure in infants has been linked to elevated bilirubin levels, potentially causing brain damage. Therefore, it is likely unsafe for infants and may pose risks during pregnancy or breastfeeding due to potential effects on the fetus or infant. It is therefore crucial to use effective contraception if considering this supplement, and to avoid its using during pregnancy or breastfeeding.
Berberine can interact with certain prescribed medications, so consult your healthcare provider or pharmacist before combining it with any medication.
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